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KMID : 0861020100250010023
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Korea Journal of Herbology
2010 Volume.25 No. 1 p.23 ~ p.31
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A Comparative Study of the Anti-cancer Effects of Smilacis Chinae Rhizoma and Smilacis Glabrae Rhizoma on Stomach Cancer SNU-1 Cells
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Ahn Han-Kyu
Han Hyo-Sang
Lee Young-Jong
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Abstract
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Objectives: The purpose of this study was to compare the anticancer effects of Smilacis Chinae Rhizoma (SCR) and Smilacis Glabrae Rhizoma (SGR) on stomach cancer SNU-1 cells.
Methods: The cell proliferation, apoptosis and cytokine level from the extracts were examined in order to compare the anticancer effects of SCR and SGR on SNU-1 cells.
Results: SCR had greater anticancer effects than SGR in terms of the inhibition of cell proliferation and apoptosis in the SNU-1 cells. SCR decreased TGF-β and SGR increased IL-2 in SNU-1 cells. SCR decreased more TGF-β and increased more TNF-α compared to SGR.
Conclusions: There were few significant differences according to the concentration and fraction, but a greater anticancer effect of SCR was shown as compared with SGR.
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KEYWORD
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Smilax china Linne, Smilax glabra Roxb, Smilacis Chinae Rhizoma, Smilacis Glabrae Rhizoma, anticancer effects, SNU-1
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